Hosted by the American College of Toxicology
With support from: The British Toxicology Society and the Society of Toxicologic Pathology
Education level: Foundational Emerging
Speaker: Rachel Tapp
Ototoxicity refers to the potential for certain chemicals or drugs to cause damage to the inner ear and result in hearing loss or balance problems. This type of ototoxicity can occur even in the absence of any clinical symptoms or signs of hearing loss.
Currently, there is ongoing research in this area to better understand the mechanisms by which ototoxicity occurs and to identify potential ways to prevent or mitigate its effects. Some of the key areas of focus include developing more sensitive and reliable methods for detecting ototoxicity, identifying and testing new drugs or compounds that may be less toxic to the inner ear, and exploring the use of protective agents or therapies to prevent or reduce the risk of ototoxicity.
We will discuss the nonclinical aspects and needs for these study types and how they are conducted. Overall, the goal of this research is to improve our understanding of nonclinical ototoxicity and to develop new strategies for minimizing its potential impact on individuals who may be at risk.
About the speaker:
Rachel Tapp has been working in nonclinical research since 1999 and is a graduate of MSU with her master’s degree in pharmacology and toxicology. She is a Principal Research Scientist at Charles River Laboratories, specializing in ototoxicity evaluations, and has managed over 150 studies covering this research area. Additionally, she is a member of the IOMG and HESI working groups who are tackling the necessary research and proposing guidance for safe exposures to ototoxicants and sound levels in the workplace. Rachel is also a member of the accessibility committee for the 2024–2026 Association for Research in Otolaryngology meeting. She is also an avid gardener, solar energy and sustainability advocate, scuba diver, swimmer, plant collector, and dog lover.