ACT Signature Webinars

Immunological Assessments of Viral Vectors Expressing Multiple Cytokine Transgenes in Nonclinical... 

10-18-2019 03:15 PM

Immunological Assessments of Viral Vectors Expressing Multiple Cytokine Transgenes in Nonclinical Studies

Hosted by the American College of Toxicology with support from the Society of Toxicologic Pathology

Speaker: John-Thomas Farmer, PhD, Senior Scientist/Manager of the Immunology Group Southern Research

Abstract: This presentation will present examples of common and uncommon immunological findings in nonclinical studies testing adeno virus (AV) or adeno associated virus (AAV) vectors expressing multiple cytokine transgenes. The presentation will also include challenges encountered in designing and interpreting immunological data from these studies.

About the Speaker: John-Thomas Farmer, PhD, currently serves as senior scientist/manager of the immunology group at Southern Research. Dr. Farmer has extensive experience conducting immunotoxicology studies and validating immunoassays supporting nonclinical and clinical studies. Experience includes immunotoxicology assessment of biotherapeutics including monoclonal antibodies, cytokines, therapeutic peptides/proteins, vaccines, and viral vectors in rodent, canine, and NHP models. Experience in development and validation of immunoassays supporting nonclinical and clinical studies includes ligand binding immunogenicity and biomarker assays utilizing ECL and ELISA methods. Experience in validation and conduct of functional immune system assessment includes, immunophenotyping, peripheral and intracellular cytokine analysis, cytotoxic T- lymphocyte assay, mixed lymphocyte reaction assay, neutrophil/macrophage phagocytosis assays, and assessment of complement activity. Additional experience includes clinical trial immunogenicity and biomarker analyses.

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