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Short Webinar Series
Fundamentals of Translational
Neuroscience in Toxicologic Pathology
The Society of Toxicologic Pathology (STP) Internet Committee-Web-based Education Subcommittee (WBEC) is pleased to offer these quarterly Short Education Webinar Series as an educational tool to foster collaboration among the toxicologic pathology community. The fourth of the series entitled "Fundamentals of Translational Neuroscience in Toxicologic Pathology" features five presentations from a half-day Continuing Education Course at the STP Annual Symposium held in Washington, DC (June 2014).
Extrapolation of animal data to predict possible human outcomes is an elemental conundrum in drug discovery and development. This problem often is of particular significance when investigating therapeutic candidates with neuroactive properties or that induce structural alterations in the central nervous system (CNS), especially when the portfolio management process and/or regulatory review are given to individuals with limited or no formal training in neurobiology. This session is designed to impart fundamental information on basic neurobiological principles necessary for pathologists, toxicologists, and regulators to gain confidence in their abilities to translate CNS structural changes in test animals for risk assessment in humans. The last talk is included as a practical example regarding the application of such principles to address a current issue facing many pharmaceutical companies and regulatory agencies.
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STRUCTURAL-FUNCTIONAL CORRELATIONS IN NEUROPATHOLOGY EVALUATIONS: RODENTS
Deepa Rao, BVSc, MS, PhD, DABT, DACVP, ILS/NTP, Research Triangle Park, NC
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STRUCTURAL-FUNCTIONAL CORRELATIONS IN NEUROPATHOLOGY EVALUATIONS: NON-RODENTS
Ingrid Pardo, DVM, MS, DACVP, Pfizer, Inc., Groton, CT
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PATHOLOGY CONSIDERATIONS IN DEVELOPMENTAL NEUROTOXICITY TESTING
Robert H. Garman, DVM, DACVP, Consultants in Veterinary Pathology, Inc., Murrysville, PA
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NEGLECTED FACTORS THAT MAY CONFOUND TRANSLATIONAL NEUROSCIENCE
Brad Bolon, DVM, MS, PhD, DACVP, DABT, ATS, FIATP, The Ohio State University, Columbus, OH
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POLYETHYLENE GLYCOL (PEG)—ASSOCIATED VACUOLATION IN EPITHELIAL CELLS OF THE CHOROID PLEXUS AND ITS IMPACT ON DEVELOPMENT OF PEG-CONJUGATED THERAPIES
Wolfgang Kaufmann, Dr Med Vet, FTAPath, DECVP, FIATP, Merck KGaA, Darmstadt, Germany
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The affiliations of the presenters are those in effect at the date of the presentation.
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Society of Toxicologic Pathology | 11190 Sunrise Valley Drive, Suite 300 | Reston, VA 20191
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