SOT Offers Role of Mode of Action in Dose-Response Assessment for Carcinogens Colloquium at FDA
The Society of Toxicology in conjunction with the FDA Center for Food Safety and Applied Nutrition (CFSAN) is presenting the last of a four-part colloquia series in food safety. “Role of Mode of Action in Dose-Response Assessment for Carcinogens” will be January 25, 2016, from 8:30 am-12:40 pm in Wiley Auditorium on the CFSAN campus in College Park, Maryland. Among the primary goals of a risk assessment are 1) determination of the presence or absence of a cause-effect relationship and 2) quantifying the risk through dose-response analysis. Advances in our understanding of the ways that chemicals interact with biological systems have yielded several frameworks for evaluating toxicity datasets to determine biologically plausible modes of action (MOA) and relevance to humans. These frameworks can be used to consider the weight of evidence of hypothesized MOA in animals and their potential human relevance for both cancer and non-cancer effects. This could result in a move away from defaults to adopt modern knowledge on MOA to improve risk assessments, including the choices for dose-response assessment.
This scientific training is high quality, cutting-edge, future-oriented toxicological science to provide a well-grounded, foundation to inform the work of FDA employees and depth of knowledge for others. The focus is a discussion of emerging toxicology methods and the sessions are not a public forum for discussion of toxicology regulatory issues.
We welcome participation from our colleagues who are members of American College of Toxicology (ACT).
The colloquium is open to the public to attend in person or via webcast.
Registration for on-site participation
Registration for webcast
Presentations include:
- The Role of Mode of Action in Dose-Response Assessments: Recommendations from the 2009 NRC Report “Science and Decisions,” Lauren Zeise, NRC Committee Member, Berkeley, CA
- Mode of Action, Distinguishing between Mode and Mechanism of Action, and Some Key Events for MOA, Michael Dourson, TERA, Cincinnati, OH
- The Mutagenic Mode of Action and the Choices for the Dose-Response Analysis, Rita Schoeny, US EPA (retired), Washington, DC
- Risk21 Quantitative Key Events Dose-Response Framework, J. Craig Rowlands, Dow Chemical Company, Midlands, MI
These talks will be followed with a roundtable discussion moderated by Elaine Faustman, University of Washington. Questions from the audience on-site and participating in the webcast are encouraged.
In addition, the recording and materials from the previous sessions as well as additional information can be accessed at the Colloquia website.
Questions? Contact SOT at rachelw@toxicology.org, 703.438.3115 Ext 1602.